The Marion Barnhart Memorial Lecture will be presented by Garret Fitzgerald at ISTH SSC2012
Marion Barnhart had a brilliant career in medical and scientific research and education. Her many important discoveries in the fields of cellular physiology, blood coagulation and thrombosis, platelet vessel wall interactions and other aspects of hematology won her national and international acclaim and numerous awards. Although she was 64 when she died, the Dean of Wayne State University's medical school noted that she was undoubtedly the youngest member of the faculty in terms of enthusiasm, excitement, energy, productivity, and her always upbeat, positive attitude.
Marion received the PhD degree in cellular physiology from the University of Missouri in 1950 and then came to Detroit as an instructor in physiology and pharmacology at Wayne State University School of Medicine. She was the first recipient of the Distinguished Graduate Faculty Award given at Wayne State University in 1974. Among her contributions are the description of the cellular sites for synthesis of prothrombin, fibrinogen and other blood coagulation proteins, the demonstration of the important role played by neutrophils and eosinophils in fibrin dissolution, scanning electron microscopy of the sequence of events in platelet activation and platelet-vessel wall interactions, circulatory pathways in the human spleen and the development of the human umbilical vein model for studying platelet-vessel wall interactions.
When she met her untimely death, Marion was the Director of the Bargman Laboratory for Cell and Molecular Research, was the Principal Investigator/Director of an NIH multidisciplinary training grant in Experimental Hematology, and Professor of Physiology at Wayne State University. In addition, she was chairperson of the Hemostasis Committee of the NIH's Blood Diseases and Resources Advisory committee, and a Charter member of Wayne State's Academy of Scholars. With her vibrant personality, great enthusiasm and genuine warmth, Marion touched and enriched the lives of all who were fortunate enough to interact with her. She believed in striving for excellence in whatever one did and served as a superb role model for all--not only as a scientist and educator, but a wonderful, caring human being.
The Arthur Bloom Memorial Lecture will be presented by Ted Tuddenham at ISTH SSC2012
Arthur Bloom was born in South Wales in 1930 and joined the Welsh National School of Medicine (now the School of Medicine, Cardiff University) in 1960 to work in the new discipline of Haematology. He presented his thesis in 1963 based on research into the clot promoting properties of blood cell contents and the contact activation of blood coagulation. He rapidly became a leading investigator in the field, performing pioneering basic and clinical research. This culminated in the award of a personal chair in 1976. During the 1980s he was one of the first haemostasis doctors to encourage developments in molecular biology and genetics, quickly recognizing the benefits to patients and their families.
Arthur was an outstanding figure in the world of haemophilia care and his principal commitment was to the needs of his patients and their families. He establishing a haemophilia centre in Cardiff in 1965 and made a major contribution to the development of the concept of "Comprehensive Care". He was Chairman of the UK Haemophilia Centre Directors Organisation for several years during very a difficult period. The impact of HIV left its mark on Arthur, as it did the whole haemophilia community. The change from the halcyon days of the late 1970s, when new products were beginning to revolutionize the lives of people with haemophilia, to the despair of the mid 1980s, when the full impact of HIV had become apparent, was devastating to all concerned. To provide balanced advice and practical wisdom during this time required exceptional talents, and Arthur had them in abundance.
To the people who knew him best, his most important role was to be available to give advice and encouragement. He is perhaps best described by the co-editors of the textbook Haemostasis and Thrombosis as "a gentle physician, an imaginative scientist and a wise counsellor." He died at the age of 62 years, on Thursday 12 November 1992 and has been greatly missed by family, friends and colleagues alike.
The Kenneth M. Brinkhous Memorial Lecture will be presented by Denisa Wagner at ISTH SSC 2012
Kenneth M. Brinkhous was an influential leader and charter member of the ISTH. He was one of the 16 original members of a committee organized in 1954 as the International Committee for the Standardization of the Nomenclature of the Blood Clotting Factors. This committee expanded in 1969 into the ISTH with 173 members. Dr. Brinkhous was elected as one of the founding board members of the Society and he served as the Secretary General for 12 years. His leadership of the ISTH and the SSC is recognized by this lectureship which has been endowed by a generous contribution of Wyeth.
The Life Sciences Research Partners Lecture will be presented by Markus Huber-Lang at ISTH SSC 2012
In 2000, Désiré Collen established a lectureship through a contribution to the Society from the Collen Foundation. Collen, who is the founding director of the Molecular Cardiovascular Medicine Group in Leuven, Belgium, and chief executive officer and chairman of the board of ThromboGenics Ltd., a biopharmaceutical drug development company of Ireland, established the lectureship to further the scientific mission of the Society. Eighteen years ago, he also provided a generous donation to start what is now the Reach the World program that supports the travel of young individuals from all over the world to our meetings. Author of more than 620 papers, Collen has research interests in the molecular biology and pathophysiology of hemostasis and thrombosis, the development of novel thrombolytic and antithrombotic agents, the pathogenesis and treatment of atherosclerosis, and gene targeting and gene transfer studies of the cardiovascular system. His team initially developed therapeutic tissue plasminogen activator (t-PA), a drug that revolutionized the treatment approach in patients with thrombotic disorders. Previous lectures endowed by the Collen Foundation (now Life Science Research Partners) were delivered by Judah Folkman, Charles Esmon, Ryozo Nagai, Bruce Furie, Rudolf Jaenisch and Kari KustaaAlitalo.
The Shirley Johnson Memorial Lecture will be presented by Claire McLintock at ISTH SSC 2012
Shirley Alma Johnson was born April 15, 1922 in Mervin, Saskatchewan, Canada, and died September 11, 1970 in Washington, DC. She received her PhD in Physiology from the University of Toronto in 1949. Her first position was teaching physiology at the College of Osteopathy and Surgery, Kirksville, MO. Her outstanding career in the field of coagulation was launched between 1951 and 1956 as a research associate and later as friend and colleague of Professor Walter H. Seegers in the Department of Physiology and Pharmacology at Wayne State University, Detroit, Michigan. Her early interests encompassed the plasma coagulation factors, but became focused on the ultrastructure and pathophysiology of platelets. Her later publications dealt mainly with the interaction of platelets with the fibrin clotting mechanisms and the vascular endothelium. The careful, systematic research establishing the endothelial supporting function of platelets could serve as a model for any investigators in the field of hemostasis and thrombosis.
Dr. Johnson headed the Divisions of Coagulation at the Henry Ford Hospital, Detroit (1956-1960); the Milwaukee County General Hospital (1960-1963); Wood Veterans Administration Medical Center, Milwaukee, Wisconsin (1963-1966); and the Veterans Administration Medical Center, Washington, DC (1967-1970) with faculty appointments at Wayne State University, Marquette University College of Medicine, Georgetown and George Washington Colleges of Medicine, respectively. She was a very active member in the ISTH and the early ICTH.
This lectureship is dedicated to a great lady who inspired excellence in her students and associates. She loved people, literature, music and travel. She was beloved in the international scientific community and will ever be remembered by all who knew her.
The Pia Glas-Greenwalt Memorial Lecture will be presented by Ken Kaushansky at ISTH SSC 2012
Pia Glas was born in 1932, in Sigmaringen, Germany, and studied medicine at the Eberhard-Karl University Medical School in Tubingen. The direction of her career was evident in her Doctoral thesis, which was entitled "Fibrinolgenolysis following plasminogen activation by streptokinase." She continued postdoctoral training with Dr. TageAstrup to Washington, DC, at the James F. Mitchell Foundation. She returned briefly to Tubingen for further training in medicine and certification in hematology, but came back to the Mitchell Foundation in 1970. It was there that she married TibbyGreenwalt. When Dr. Astrup retired, Dr. Glas-Greenwalt was promptly recruited to be the civilian Head of the Coagulation Division, Department of Experimental Pathology, at the Naval Research Institute in Bethesda, MD.
Dr. Glas-Greenwalt moved to the University of Cincinnati in 1979, where she continued her research in fibrinolysis. In the early 1980's, she was a pioneer in the field of plasma proteins being used as inhibitors for t-PA and urokinase. She identified increased plasma levels of what proved to be plasminogen activator inhibitor-1 in patients with systemic lupus erythematosus.
In 1990, Dr. Glas-Greenwalt moved to the Good Samaritan Hospital to create and direct a state-of-the-art Fibrinolysis/Special Coagulation laboratory. She had long investigated the properties and therapeutic uses of the defibrinating enzyme Ancrod, and at the time of her death in 1996, she was engaged in laboratory analyses for 600 patients, in a study of Ancrod as therapy for ischemic stroke.